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Kafukufuku watsopano akupita patsogolo pa gallic acid

6ba5b362475a44a843bb9439767aa57f1. Anti-chotupa zotsatira

1) Kuletsa mapangidwe chotupa;kupanga chotupa ndi zinthu zambiri, masitepe ambiri, masinthidwe amitundu yambiri.Zimadziwika kuti ma carcinogens ambiri amatha kuyambitsa ndi kulimbikitsa mapangidwe a chotupa, ndipo gallic acid imakhala ndi zoletsa komanso zoletsa pamagawo onse a chotupacho.Gallic acid imatha kulepheretsa kukulitsa khansa ya guanylate decarboxylase (ODC).

2) Cytotoxicity: Gallic acid imatha kuletsa ndikupha mwachindunji maselo otupa.Poyang'ana mankhwala odana ndi chotupa ndi njira zamankhwala achi China, anapeza kuti pamene IC inali 4.8 ~ 13,2ml, GA inawonetsa zotsatira za cytotoxic pa hepatocytes ya makoswe ndi macrophages, ndipo inasonyeza fibroblasts ndi maselo otsiriza.Kuchepa kwa cytotoxicity.

3)) Kuletsa kwa chotupa angiogenesis: Angiogenesis ndi njira yofunika kwambiri ya pathological pakukula kwa chotupa ndi metastasis, ndipo kuyambitsa, kuchulukana, kusamuka komanso kupanga tubule kwa ma cell endothelial cell (VEC) ndi njira zake zazikulu.Kafukufukuyu adapeza kuti gallic acid imalepheretsa kukula kwa mitsempha yamagazi yotupa chifukwa cha synergistic kapena stimulatory zotsatira pakati pa gallic acid ndi zina zosavomerezeka, zomwe zikuwonetsa dongosolo lachilengedwe komanso losavuta kuwongolera, komanso anti-VEC kusinthika kwa gallic acid.Perekani umboni wachipatala.

4) Monga chinthu cha polyphenolic, GA ili ndi antioxidant wamphamvu komanso anti-free radical effects.Kuwonongeka kwaoxidative ndi free radical kumadziwika kuti ndi imodzi mwamakina ofunikira omwe amayambitsa kuwonongeka kwa ma cell a DNA ndikuyambitsa zilonda zama cell.

5) Kulowetsedwa kwa chotupa cell apoptosis: malipoti a kafukufuku akuwonetsa kuti kukhudzika kwa GA kukopa apoptosis sikusintha ndi kukana kwa cisplatin, kusonyeza kuti GA ingagwiritsidwe ntchito pochiza khansa ya m'mapapo, makamaka khansa ya m'mapapo yomwe imalimbana ndi mankhwala oletsa chotupa.

2. Zomwe zimachitika pachiwindi

Ofufuza aku China amakhulupirira kuti GA ili ndi zotsatira za anti-HBV.Anti-Hepatitis B Virus Surface Antigen (HBSAg) ndi Hepatitis B Virus e Antigen (HBeAg) adaphunzira moyesera, pogwiritsa ntchito ukadaulo wa enzyme-linked immunosorbent assay (ELISA) kusankha mitundu 4 ya GA, Yunzhi Gantai, Yigan Granule ndi Yiganning Drug efficacy test. .GA ndi mankhwala othandiza polimbana ndi HBSAg/HBeAg yowonetsedwa mu labotale.

3. Zotsatira za mitsempha ya magazi

Mphamvu ya mitsempha ya GA pa murine thoracic aorta inaphunziridwa, ndipo inasonyezedwa kuti GA inali ndi zotsatira za vasoconstrictive pa mitsempha yowonongeka yowonongeka yomwe imachitidwa ndi phenylephrine kapena prostaglandin F (2/), pamene GA inalibe zotsatira za vasoconstrictive pa endothelial yamaliseche. mitsempha.

4. Kupewa ndi kuchiza Edzi

Gall tannins ndi esters of gallic acid ndi polyols monga glucose, quinic acid, shikimic acid, etc. Mitundu yodziwika bwino ya gallic tannins ndi: tannins (Chinese gall tannins), shirataki tannins ndi tara tannins.Ma gall tannins nthawi zambiri amakhala osakanikirana a esters okhala ndi magawo osiyanasiyana owirikiza kawiri.Gallotannin ndiye mtundu waukulu wa tannin womwe umagwiritsidwa ntchito pofufuza za HIV.

5. Trypanicidal action

Nyongolotsi za ku Africa ndi tizilombo toyambitsa matenda timene timayambitsa tulo mwa anthu ndi nyama.

6. Kwa odana ndi kutupa, bacteriostatic ndi antiviral zotsatira

Zotsatira zotsutsana ndi kutupa ndi bacteriostatic za gallic acid zinaphunziridwa, ndipo zinawonetsedwa kuti gallic acid inali ndi zotsatira pa kutupa kwa makoswe oyesera chifukwa cha dzira loyera, dextran, 5-hydroxytryptamine ndi formaldehyde, zomwe zimayimira kutupa kwakukulu.Imakhala ndi anti-inflammatory effect;tengani gallic acid wambiri, onjezerani madzi opera ndi kusungunula, ndikuwonjezera ku 9ml agar sing'anga.Gallic acid imalepheretsa kwambiri Escherichia coli, Staphylococcus aureus, Pasteurella, ndi Streptococcus.Ntchito ya anti-NDV virus yogwira ntchito ya monomer gallic acid mu tiyi ya Pu-erh idatsimikiziridwa ndi njira ya cytopathic.Zotsatira zikuwonetsa kuti gallic acid ili ndi anti-NDV virus ntchito.Kuyesa kugwiritsa ntchito ma cell kuti muwone momwe gallic acid imakhudzira PPAK receptors


Nthawi yotumiza: Jul-08-2022