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Kuphatikiza kwa gallic acid ndi kutambasula kumachepetsa zizindikiro zotupa za nyamakazi m'maselo

Timagwiritsa ntchito makeke kuti tikulitse zomwe mumakumana nazo.Mukapitiliza kuyang'ana webusayiti iyi, mukuvomera kugwiritsa ntchito makeke.Zambiri.
Gulu lotsogozedwa ndi ofufuza ochokera ku yunivesite ya Washington State linagwiritsa ntchito gallic acid (antioxidant yomwe imapezeka mu gallnut, tiyi wobiriwira, ndi zomera zina) ndipo inagwiritsa ntchito njira yotambasula kwa chondrocyte yaumunthu yotengedwa kuchokera ku mawondo a nyamakazi.Tsanzirani kutambasula komwe kumachitika mukuyenda.Kuphatikiza kumeneku sikungochepetsa zizindikiro zotupa za nyamakazi m'maselo, komanso kumawonjezera kupanga mapuloteni omwe amafunidwa omwe amapezeka mu cartilage yathanzi.
Ngakhale akadali m'magawo oyambirira, zotsatira zafukufuku zimasonyeza kuti njira yatsopano ingapangidwe kuti ipangitse maselo a cartilage otengedwa kuchokera kwa odwala kuti akule maselo kapena minyewa kuti abwezeretsedwenso.
Tinapeza kuti kutambasula pamodzi kuli ngati kuchita masewera olimbitsa thupi pa selo lokha, kuphatikizapo gallic acid kumachepetsa zizindikiro zotupa, zomwe zikutanthauza kuti tikhoza kusintha osteoarthritis.Zili ngati kuchita masewera olimbitsa thupi komanso kudya zakudya zabwino pamlingo wocheperako.”
Phunziroli, lofalitsidwa mu Experimental Cell Research, ofufuza adasonkhanitsa maselo a osteoarthritis a cartilage kuchokera ku mawondo operekedwa omwe adatengedwa panthawi ya opaleshoni yolowa m'malo pa Pullman Regional Hospital.Analima maselo mu labotale ndipo adayesa "zakudya" zisanu ndi chimodzi za antioxidant kapena zakudya zopatsa thanzi, kuphatikiza vitamini C, vitamini E, ndi curcumin.Ma antioxidants amatha kusokoneza ma free radicals, omwe ndi maatomu osakhazikika omwe amayamba chifukwa cha kupsinjika kwa okosijeni, komwe kumatha kuwononga ma cell ndi minofu.
Mayeso a labotale akuwonetsa kuti gallic acid ndiye antioxidant yothandiza kwambiri pakuchepetsa ma radicals aulere m'ma cell a osteoarthritis cartilage.Kenaka, ofufuzawo adagwiritsa ntchito selo lotambasula lomwe linapangidwa ndi Curi Bio Inc. kuti agwiritse ntchito gallic acid ndikuwonjezera kutambasula.Amayika kutambasula ku 5%, mlingo womwe umafanana ndi kutambasula kwa bondo pamene munthu akuyenda.
Kuphatikiza uku kumachepetsa zolembera zotupa zomwe zimatchedwa matrix metalloproteinases.Imawonjezera kuyika kwa collagen ndi glycosaminoglycans, izi zimapanga minofu yolumikizana ndi umphumphu, kulimba kwamphamvu komanso kutha kukana kukakamiza kwa kulemera kwa thupi pamfundo.Kutambasula ndi gallic acid kumawonjezeranso kufotokoza kwa mapuloteni ena awiri okhudzana ndi cartilage.
Osteoarthritis ndi matenda ofala kwambiri a minofu ndi mafupa padziko lapansi.Imawononga chichereŵechereŵe m'malo olumikizirana mafupa, imayambitsa kupweteka komanso imalepheretsa kuyenda.Panopa palibe mankhwala athunthu.Zochizira zimachokera ku kupereka mankhwala opha ululu kupita ku opaleshoni kuti alowe m'malo ophatikizana ndi mankhwala opangidwa, koma ngakhale opaleshoniyo salola kuti wodwalayo abwerere ku masewera olimbitsa thupi.
Njira ina imatchedwa autologous chondrocyte implantation kapena ACI, yomwe imaphatikizapo kuchotsa ma cell a cartilage kuchokera pamgwirizano, kuwakulitsa mpaka chiwerengero chachikulu, ndiyeno kuwaikanso.Ofufuzawo adanenanso kuti pakali pano, maselo sakukonzedwanso asanakhazikitsidwenso, ndipo kusowa kwa chithandizo kungachititse kuti maselo akule ofooka fibrocartilage.Angakhudzidwenso ndi nyamakazi ya osteoarthritis, ndipo njirazi sizidzabwezeretsa kugwira ntchito kwathunthu kwa mafupa.Kafukufukuyu akuwonetsa njira yopangira njira yofananira poyambira pokonza ma chondrocyte ndipo panthawi imodzimodziyo amakula kukhala minyewa yomwe imatha kubwezeretsedwanso.
"Tikupita patsogolo ukadaulo wopanga ma cartilage osinthika mu labotale.Ma cartilage amenewa akhoza kuikidwa mu zilonda za cartilage, motero kuchepetsa chiwerengero cha malo olowa m'malo, "anatero Bernard W. Wojland, pulofesa wa Sukulu ya Chemical Engineering ndi Bioengineering.Anatero Bernard Van Wie.Wofufuza wamkulu ndi wolemba wofanana."Tikufuna kupanga cartilage yachilengedwe yomwe imagwira ntchito bwino kuyambira pachiyambi, m'malo molowa m'malo olumikizirana mafupa."
Kafukufukuyu akuwonjezera umboni wakuti kudya zakudya zokhala ndi antioxidant komanso kuchita masewera olimbitsa thupi kungakhale kopindulitsa, ngakhale ochita kafukufuku akuchenjeza kuti gallic acid sayenera kuonedwa ngati panacea, ndipo njira iliyonse iyenera kufunsidwa ndi dokotala wa munthuyo.
"Izi zimapereka umboni wina woti zakudya zabwino komanso masewera olimbitsa thupi ndizothandiza," adatero Abusharkh.Ngakhale kwa anthu omwe ali ndi nyamakazi yochepa, masewera olimbitsa thupi ndi abwino.Minofu yathu ya cartilage ndi yoipa kwambiri tikagona kapena kukhala tsiku lonse;tikuyenera kuchita zinazake."
Kafukufukuyu adathandizidwa ndi National Science Foundation ndi National Health Protein Biotechnology Training Program Institute.
Abu Shak, Ha ndi ena.(2021) Phatikizani kutambasula ndi gallic acid kuti muchepetse index yotupa ndikulimbikitsa kupanga matrix owonjezera mu osteoarthritis human articular cartilage cell.Kafukufuku wama cell.doi.org/10.1016/j.yexcr.2021.112841.
Tags: antioxidant, nyamakazi, bioengineering, biotechnology, cartilage, maselo, kolajeni, kufunsira, curcumin, zakudya, dokotala, masewera olimbitsa thupi, free radicals, tiyi wobiriwira, chipatala, kutupa, labotale, yaying'ono, minofu ndi mafupa, mafupa Nyamakazi, oxidative nkhawa, ululu, pH, mapuloteni, kafukufuku, nkhawa, opaleshoni, tiyi, vitamini C, vitamini E, kuyenda
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Nthawi yotumiza: Dec-22-2021